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Recruitment was stopped early when an interim analysis showed an increased rate of death at 36 weeks in the group with a lower oxygen saturation.
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For this purpose, the purified, randomized C-terminal TetR(D) fragments were resuspended in PCR mixture (02 mM each dNTP, 22 mM MgCl 2, 50 mM KCl, 10 mM Tris-HCl, pH 90, 01% Triton X-100) at a concentration of 10-30 ng/μl and Taq DNA polymerase was added to the reaction mixture (25 Units/100 μl)!